Delivery System for RNA based Therapy of Cardiovascular Diseases A Systematic Review (Data).xlsx

This dataset comprises detailed information extracted from a systematic review of 18 studies that investigated RNA-based therapies for various cardiovascular diseases using murine models. The reviewed cardiovascular conditions include myocardial infarction, cardiomyopathy, systemic hypertension, atherosclerosis, coronary heart disease, heart failure, myocarditis, and endothelial dysfunction. The dataset highlights the following key aspects:<b>RNA Delivery Methods:</b> The studies explored different RNA delivery systems, including viral vectors, lipid nanoparticles, and polymer nanoparticles.<b>Administration Routes:</b> The primary routes of administration were direct tissue injection and intravenous injection.<b>Impact on RNA Levels:</b> Changes in RNA levels post-therapy were reported in 15 studies, with varying impacts depending on the delivery vehicle used.<b>Effects on Target Proteins:</b> Thirteen studies documented the effects on specific target proteins.<b>Clinical Outcomes:</b> Seventeen studies reported achieving desired clinical outcomes following the induction of RNA therapy.

这个数据集包含从18项研究的系统综述中提取的详细信息，这些研究利用小鼠模型（murine models）探究了针对多种心血管疾病的RNA疗法。综述涵盖的心血管疾病包括心肌梗死、心肌病、系统性高血压、动脉粥样硬化、冠心病、心力衰竭、心肌炎和内皮功能障碍。数据集重点突出以下关键方面：<b>RNA递送方法：</b>研究探索了不同的RNA递送系统，包括病毒载体、脂质纳米颗粒和聚合物纳米颗粒。<b>给药途径：</b>主要给药途径为直接组织注射和静脉注射。<b>对RNA水平的影响：</b>15项研究报告了治疗后RNA水平的变化，其影响因所用递送载体而异。<b>对靶蛋白的影响：</b>13项研究记录了对特定靶蛋白的影响。<b>临床结局：</b>17项研究报告称，在实施RNA疗法后达到了预期的临床结局。