Dataset from Assessment of Inflammatory Markers Associated with Neurocognitive Impairment in HIV-infected Adolescents, a Sub-study of ATN 071

A sub-study of ATN 071 ("Neurocognitive Assessment in Youth Initiating HAART"), ATN 101 was an exploratory assessment comparing the results of a comprehensive neurocognitive evaluation carried out through ATN 071 to biomarkers within the plasma that correlate with immune activation, inflammation, and microbial translocation among study participants. Neurocognitive evaluations from ATN 071 were available for three years of follow-up; blood samples for ATN 101 were collected at the final ATN 071 study visit. In a subset of participants co-enrolled in ATN 061 ("Preservation and Expansion of T-cell Subsets Following HAART De-intensification to Atazanavir/ritonavir (ATV/r) in Adolescents and Young Adults with CD4 + T Cells > 350 cells/mm3 Initiating HAART), biomarkers were evaluated before and after the initiation of HAART. Some biospecimens are available; for inquiries, please contact Dr. John Sleasman ([e-mail]).

本研究为ATN 071（《青少年启动高效抗逆转录病毒治疗后的神经认知评估》，Neurocognitive Assessment in Youth Initiating HAART）的亚研究。ATN 101为一项探索性评估，旨在对比ATN 071所开展的全面神经认知评估结果，与研究参与者血浆中与免疫激活、炎症及微生物易位相关的生物标志物。ATN 071的神经认知评估数据覆盖3年随访周期；ATN 101的血液样本采集于ATN 071研究的最后一次访视时点。对于共纳入ATN 061（《启动高效抗逆转录病毒治疗且CD4+T细胞＞350cells/mm³的青少年及年轻成人，经降阶梯治疗为阿扎那韦/利托那韦（ATV/r）后T细胞亚群的维持与扩增》，Preservation and Expansion of T-cell Subsets Following HAART De-intensification to Atazanavir/ritonavir (ATV/r) in Adolescents and Young Adults with CD4 + T Cells > 350 cells/mm3 Initiating HAART）亚组的参与者，研究人员在其高效抗逆转录病毒治疗启动前后分别评估了生物标志物。部分生物样本可供获取；如有咨询需求，请联系约翰·斯利斯曼（John Sleasman）博士，邮箱：[e-mail]。