Chromatin regulator EP400 in oocytes controls maternal-to-embryonic transition in mice

Maternal Ep400, a component of the TIP600-EP400 complex, is required for oocyte quality and early embryo development in mice. Ep400 deficiency in mouse oocytes had minimum disturbance on oocyte transcriptome. In mouse preimplantation embryos, EP400 was found to occupy active chromatin regions to promote global transcription activity.

母源性EP400（Maternal Ep400）作为TIP600-EP400复合物（TIP600-EP400 complex）的组分之一，对小鼠卵母细胞质量与早期胚胎发育不可或缺。小鼠卵母细胞中Ep400的缺失仅对卵母细胞转录组（transcriptome）产生极轻微的扰动。在小鼠植入前胚胎（preimplantation embryos）中，研究发现EP400可结合活性染色质区域，以促进全局转录活性。