Induction of adult cardiomyocyte renewal by Klf1

In highly regenerative animals, cardiac regeneration occurs innately through cardiomyocyte dedifferentiation and proliferation, although the regenerative mechanisms remain unclear. This project contains processed data sets that were used to identify that klf1, a Kruppel-like transcription factor essential for red blood cell development, is also necessary and sufficient in the myocardium for the induction of cardiomyocyte dedifferentiation and proliferation in adult zebrafish hearts. Raw data has been deposited to PRJNA551130

在具备高度再生能力的动物中，心脏再生可通过心肌细胞（cardiomyocyte）的去分化（dedifferentiation）与增殖（proliferation）天然实现，尽管其具体再生调控机制尚未完全阐明。本项目包含经过预处理的数据集，该数据集被用于证实：KLF1（klf1）作为一种对红细胞发育至关重要的Krüppel样转录因子（Kruppel-like transcription factor），在心肌组织（myocardium）中同样是诱导成年斑马鱼（zebrafish）心脏内心肌细胞去分化与增殖的必要且充分条件。原始数据已提交至PRJNA551130。