Gene expression of livers from Lpcat3fl/fl and Lpcat3fl/fl Albumin-Cre mice on chow diet

The total abundance of phosphatidylcholine (PC) is known to influence lipoprotein production. However, the role of specific phospholipid species in lipid transport has been difficult to assess due to an inability to selectively manipulate membrane composition in vivo. Here we show that the LXR-regulated phospholipid remodeling enzyme lysophosphatidylcholine acyltransferase 3 (Lpcat3) is a critical determinant of membrane phospholipid composition and lipoprotein production. Mice lacking Lpcat3 in the liver show defects in lipoprotein production. The objective of generating this dataset was to analyze the effects of Lpcat3 loss of function on baseline gene expression in mouse liver. This dataset compares gene expression in Lpcat3fl/fl and Lpcat3fl/fl Albumin-Cre liver samples from 12-week old male mice that were subjected to 6 hr fasting. Each sample contains tissues from 5 mice.

已知磷脂酰胆碱（phosphatidylcholine，PC）的总含量会影响脂蛋白的生成。然而，由于无法在体内选择性调控膜成分，特定磷脂种类在脂质转运中的作用长期难以评估。本研究证实，受肝X受体（liver X receptor，LXR）调控的磷脂重塑酶溶血磷脂酰胆碱酰基转移酶3（lysophosphatidylcholine acyltransferase 3，Lpcat3）是决定膜磷脂组成与脂蛋白生成的关键因子。肝脏中特异性缺失Lpcat3的小鼠会出现脂蛋白生成缺陷。本数据集的构建目的为分析Lpcat3功能缺失对小鼠肝脏基础基因表达的影响。本数据集对比了12周龄雄性小鼠在禁食6小时后的肝脏组织基因表达情况，样本分为Lpcat3fl/fl组与Lpcat3fl/fl 白蛋白-Cre（Albumin-Cre）组，每份样本均取自5只小鼠的组织。