Loss of Fatty Acid Degradation by Astrocytic Mitochondria Triggers Neuroinflammation and Neurodegeneration

To investiaged the role of astrocytic mitochondrial function in regulating brain function, we depleted the Tfam gene specifically in astrocytes of mouse brains (TfamAKO). Gene expression profiling analysis was performed using data obtained from the RNA-seq of the hippocampus of WT and TfamAKO mice. Overall design: Comparative gene expression profiling analysis of RNA-seq data generated from five WT and five TfamAKO mice at 6-month-of-age.

为探究星形胶质细胞线粒体功能在调控大脑功能中的作用，我们在小鼠大脑星形胶质细胞中特异性敲除Tfam基因，构建得到TfamAKO模型。本研究采用野生型（Wild Type，WT）与TfamAKO小鼠的海马体RNA测序（RNA-seq）数据，开展基因表达谱分析。
实验整体设计：针对6月龄的5只野生型小鼠与5只TfamAKO小鼠的RNA测序数据，进行对比基因表达谱分析。