Bcl-2 overexpression effects in rat neural precursor cells.
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE130481
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Bcl-2 is highly enriched in the nervous system during neural development and plays an important role in modulating cell survival. In addition to its anti-apoptotic function, Bcl-2 has previously been suggested as a mediator of neuronal differentiation. However, the mechanism by which Bcl-2 might influence neurogenesis is not sufficiently understood. We aimed to determine the non-apoptotic functions of Bcl-2 during neuronal differentiation. Two-condition experiments, Vector/-bFGF (Induction of neuronal differentiation) vs rBcl-2/+bFGF (Bcl-2 overexpression)
Bcl-2（B-cell lymphoma 2）在神经发育过程中于神经系统内高度富集，并在调控细胞存活方面发挥重要作用。除其抗凋亡功能外，既往研究已提出Bcl-2可作为神经元分化的介导因子。然而，Bcl-2影响神经发生的具体机制尚未得到充分阐明。本研究旨在探究Bcl-2在神经元分化过程中的非凋亡相关功能。本实验采用双条件分组对照：载体/无碱性成纤维细胞生长因子（Vector/-bFGF，诱导神经元分化组）与重组Bcl-2/加碱性成纤维细胞生长因子（rBcl-2/+bFGF，Bcl-2过表达组）
创建时间：
2021-05-24
