Identification of CEBPA and RUNX1 interactors in 3q-rearranged AML (MOLM-1)

Chromatin immunoprecipitation with specific isolation of chromatin associated proteins (ChIP-SICAP) was used to identify chromatin-bound interactors of CEBPA and RUNX1 in the 3q-rearranged human myeloid leukemia cell line MOLM-1.

本研究采用染色质免疫沉淀联合染色质结合蛋白特异性分离技术（ChIP-SICAP），在3号染色体长臂重排的人类髓系白血病细胞系MOLM-1中，鉴定了CCAAT增强子结合蛋白α（CEBPA）与Runt相关转录因子1（RUNX1）的染色质结合互作蛋白。