Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA

The U7 snRNP. This particle contains the U7 snRNA, the smallest of the snRNAs which varies from 57-70 nts long depending on the species. The 5’ end of U7 snRNA binds to a sequence 3’ of the stemloop, termed the histone downstream element (HDE). There are a number of proteins found in the U7 snRNP. There are 7 Sm proteins, as are present in the spliceosomal snRNP. Five of these proteins are the same as ones found in the spliceosomal snRNPs and there are 2, Lsm10 and Lsm11 that are unique to U7 snRNP.

U7小核RNA颗粒。该颗粒含有U7小核RNA，其为snRNA家族中最小的一员，其长度介于57至70个核苷酸之间，具体长度取决于物种。U7小核RNA的5'端与茎环结构下游的序列相结合，这一序列被称为组蛋白下游元件（HDE）。U7 snRNP中存在多种蛋白质。其中包含7种Sm蛋白质，这与spliceosomal snRNP中的含量相同。其中5种蛋白质与spliceosomal snRNPs中的蛋白质相同，另外2种，即Lsm10和Lsm11，是U7 snRNP所独有的。