Homo sapiens Raw sequence reads-PNI/NC. Homo sapiens

In this study, we aim to investigate how sleep deprivation promotes the synthesis and secretion of CNS-derived GABA, regulates FOS expression in CRC cells, and interacts with Schwann cells to drive CRC perineural invasion.

本研究旨在探究睡眠剥夺如何促进中枢神经系统（Central Nervous System, CNS）来源的γ-氨基丁酸（γ-aminobutyric acid, GABA）的合成与分泌，调控结直肠癌（Colorectal Cancer, CRC）细胞中FOS的表达，并与雪旺细胞（Schwann Cells）相互作用以驱动结直肠癌的神经周围浸润（Perineural Invasion）。