Disruption of dNTPs Homeostasis by Ribonucleotide Reductase Hyperactivation Overcomes AML Differentiation Blockade II. Disruption of dNTPs Homeostasis by Ribonucleotide Reductase Hyperactivation Overcomes AML Differentiation Blockade II

We assessed global gene expression changes in nelarabine (NEL)-treated AML cell lines (U937 and KG1A) Overall design: Expression profiling data in NEL-treated cells (4 replicates) were compared to vehicle (VEH) control cells (4 replicates) by RNA sequencing

本研究评估了经奈拉滨（nelarabine，NEL）处理的急性髓系白血病（Acute Myeloid Leukemia，AML）细胞系U937与KG1A的全基因组基因表达变化。整体实验设计：采用RNA测序（RNA sequencing）技术，将经NEL处理的细胞（4个生物学重复）与溶剂对照（vehicle，VEH）细胞（4个生物学重复）的表达谱数据进行对比。