Transcriptomic analysis of human bronchial epithelium reveals unique immune landscape in severe asthma

Airway epithelial transcriptome analysis of severe asthma (SA) patients was used to identify the immune infiltration mechanisms that affect asthma exacerbation, which may contribute to improving asthma therapy. A serises of bioinformatics methods were utilized to identify the hub genes and signaling pathways in SA.本数据集针对重症哮喘（Severe Asthma, SA）患者开展气道上皮转录组分析，旨在明确影响哮喘急性加重的免疫浸润机制，以期为哮喘治疗方案的优化提供支撑。研究采用一系列生物信息学方法，鉴定出SA中的核心基因与信号通路。