Infection of ratites with clade 2.3.4.4b HPAIV H5N1: Potential implications for zoonotic risk

We detected H5N1 high pathogenicity avian influenza in captive Greater Rhea (Rhea americana). Viral genetic analysis revealed the mammalian associated PB2-E627 K mutation, indicating selection of mammalian-relevant mutations in ratites. Pathologic investigation of available tissues demonstrated severe multifocal necrotising inflammation, and a strong vasculotropism.

我们在圈养的大美洲鸵（Greater Rhea, Rhea americana）体内检测到H5N1高致病性禽流感（H5N1 high pathogenicity avian influenza）。病毒遗传分析显示该毒株携带与哺乳动物相关的PB2-E627K突变，提示平胸类鸟类（ratites）中出现了哺乳动物适配性突变的选择。对可获取组织的病理学检查结果显示存在严重的多灶性坏死性炎症，且病毒呈现显著的嗜血管性（vasculotropism）。