Dysregulation of microRNAs in neurodegeneration

This dataset contains small RNA-seq data from six Alzheimer disease, three tangle-predominant dementia and seven control brains. Total RNA was isolated from human post-mortem autopsy brain and small RNA-seq was performed as described [Hafner, M., Renwick, N., Brown, M., Mihailovic, A., Holoch, D., Lin, C., Pena, J.T., Nusbaum, J.D., Morozov, P., Ludwig, J., et al. RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries. RNA. 2011; 17(9):1697-1712]

本数据集包含6例阿尔茨海默病患者、3例以缠结为主型痴呆患者以及7例对照个体的大脑组织小RNA测序数据。总RNA提取自人类死后解剖获取的脑组织，小RNA测序操作遵循文献[Hafner M, Renwick N, Brown M, Mihailovic A, Holoch D, Lin C, Pena JT, Nusbaum JD, Morozov P, Ludwig J, 等. 深度测序小RNA cDNA文库中微小RNA（miRNA）表征的RNA连接酶依赖性偏倚. RNA, 2011, 17(9):1697-1712]中所述方法进行。