Bulk RNA-sequencing in Ldlr-/- or Ch25h-/-;Ldlr-/- peritoneal macrophages treated with LPS

Here we study the effect of LPS in the transcriptome of thioglycollate-elicited peritoneal macrophages isolated from Ldlr knock out and Ch25h;Ldlr double knock out mice Overall design: mRNA profiles from thioglycollated-elicited peritoneal macrophages isoaltes from LDLR KO CH25H;LDLR DKO mice

本研究旨在探讨脂多糖（Lipopolysaccharide, LPS）对分离自低密度脂蛋白受体（Ldlr）敲除以及胆固醇25-羟化酶（Ch25h）联合低密度脂蛋白受体双敲除小鼠的硫代乙醇酸诱导腹腔巨噬细胞转录组的影响。实验设计概况：取自Ldlr敲除、Ch25h;Ldlr双敲除小鼠的硫代乙醇酸诱导腹腔巨噬细胞的mRNA转录谱。