FstSNP-HapMap3

The International HapMap Project has recently made available genotypes and frequency data for phase 3 (NCBI build 36, dbSNP
b129) of the HapMap providing an enriched genotype dataset for approximately 1.6 million single nucleotide polymorphisms
(SNPs) from 1,115 individuals with ancestry from parts of Africa, Asia, Europe, North America and Mexico. In the present
study, we aim to facilitate pharmacogenetics studies by providing a database of SNPs with high population differentiation
through a genomewide test on allele frequency variation among 11 HapMap3 samples. Common SNPs with minor allele
frequency greater than 5% from each of 11 HapMap3 samples were included in the present analysis. The population
differentiation is measured in terms of fixation index (Fst), and the SNPs with Fst values over 0.5 were defined as highly
differentiated SNPs.

国际人类基因组单体型图计划（International HapMap Project）近期公开发布了其第三阶段的基因型与频率数据（对应NCBI参考组装版本36、dbSNP b129），该数据集包含来自非洲、亚洲、欧洲、北美及墨西哥人群的1115名个体的约160万个单核苷酸多态性（single nucleotide polymorphisms, SNPs）的丰富基因型数据。本研究旨在通过对11个HapMap3样本的等位基因频率变异开展全基因组检测，构建具备高度群体分化特征的SNP数据库，以助力药物基因组学相关研究。本分析纳入了11个HapMap3样本中次要等位基因频率大于5%的常见SNP。群体分化程度以固定指数（fixation index, Fst）进行量化，将Fst值大于0.5的SNP定义为高度分化SNP。