DataSheet_1_Animal Toxicology Studies on the Male Reproductive Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin: Data Analysis and Health Effects Evaluation.zip

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a well-known environmental poison that exist in the environment for many years. However, its effect on the male reproductive system has not been clearly stated. We conducted a meta-analysis of the effect of TCDD on the male reproductive system of rodents about TCDD. Results showed that that TCDD exposure reduced the testis weight (weighted mean difference [WMD]: −0.035, 95% confidence interval [CI]: −0.046 to −0.025), sperm count (WMD: −35, 95% CI: −42.980 to −27.019), and blood testosterone concentration (WMD: −0.171, 95% CI: −0.269 to −0.073). According to our research results, TCDD can cause damage to the male reproductive system of rodents through direct or indirect exposure. In order to further explore the potential hazards of TCDD to humans, more human-related research needs to be carried out.

2,3,7,8-四氯二苯并对二噁英（2,3,7,8-Tetrachlorodibenzo-p-dioxin，TCDD）是一种可在环境中长期残留的知名环境毒物，但其对雄性生殖系统的具体影响尚未明确阐明。本研究针对TCDD对啮齿类动物雄性生殖系统的影响开展了荟萃分析。结果显示，TCDD暴露可降低睾丸重量（加权均数差[WMD]：−0.035，95%置信区间[CI]：−0.046 至 −0.025）、精子数量（WMD：−35，95% CI：−42.980 至 −27.019）及血液睾酮浓度（WMD：−0.171，95% CI：−0.269 至 −0.073）。基于本研究结果，TCDD可通过直接或间接暴露途径损伤啮齿类动物的雄性生殖系统。为进一步探明TCDD对人类的潜在危害，尚需开展更多与人类相关的研究工作。