Adipocyte-derived extracellular vesicles regulate survival and function of pancreatic ß-cells

We explored the effects of extracellular vesicles (EVs), released from both rodent and human isolated adipocytes, on survival and function of pancreatic ß-cells and human pancreatic islets. Overall design: Analysis of differential expression of microRNAs in EVs from healthy and inflamed 3T3-L1 and human primary adipocytes

本研究探讨了从啮齿类与人类分离的脂肪细胞释放的细胞外囊泡（extracellular vesicles, EVs）对胰腺β细胞及人类胰岛存活与功能的影响。总体实验设计：分析健康与炎症状态下3T3-L1细胞及人类原代脂肪细胞来源的细胞外囊泡中微小RNA（microRNAs）的差异表达。