成人人类弱视中膝状体纹状体路径数据集

早期生活中异常的视觉体验如何影响人类皮层下路径尚不清楚。我们使用高分辨率的功能性磁共振成像（fMRI）和选择性视觉刺激来研究弱视对成人人类大脑皮层下视觉路径的反应特性和有效连通性的影响。与正常眼和同侧眼相比，呈现给弱视眼的刺激在外侧膝状体的细胞层中显示出选择性减少的反应，在与V1的有效连通性也较弱。与正常眼相比，弱视眼对色彩刺激的反应在上丘的表层减少，而同侧眼在深层SC的反应则明显增强，并且从视觉皮层的连通性更强。因此，弱视导致膝状体纹状体路径和皮质盖层路径的细胞层选择性改变。这些发现为弱视引起的视力、眼球运动控制和注意力缺陷提供了神经基础。

It remains unclear how abnormal visual experiences during early life affect the subcortical visual pathways in humans. We used high-resolution functional magnetic resonance imaging (fMRI) and selective visual stimuli to investigate the effects of amblyopia on the response properties and effective connectivity of subcortical visual pathways in the adult human brain. Compared with stimuli presented to the non-amblyopic eye and the ipsilateral eye, stimuli presented to the amblyopic eye exhibited selectively reduced responses in the cellular layers of the lateral geniculate nucleus, and showed weaker effective connectivity with V1. Compared with the non-amblyopic eye, the amblyopic eye showed reduced responses to chromatic stimuli in the superficial layers of the superior colliculus (SC), whereas the ipsilateral eye exhibited significantly enhanced responses in the deep layers of SC and had stronger connectivity from the visual cortex. Thus, amblyopia leads to selective alterations in the cellular layers of both the geniculostriate pathway and the corticotectal pathway. These findings provide a neural basis for the visual, oculomotor control, and attentional deficits caused by amblyopia.