LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche [preleukemic and leukemic cells]. Mus musculus

We used microarrays to investigate gene expression changes in tumor-bearing Sca1-TOMATO-Lmo2 mice and in preleukemic cells from Sca1-TOMATO-Lmo2 mice. Overall design: Tumor-bearing thymus of eleven Sca1-TOMATO-Lmo2 mice compared with thymus cells from 4 WT mice, with TOMATO-positive thymus preleukemic T cells from 5 Sca1-TOMATO-Lmo2 mice and with TOMATO-negative thymus preleukemic T cells from 5 Sca1-TOMATO-Lmo2 mice GSM2209749 - GSM220975 and GSM2209757 - GSM2209759 were re-analyzed by GSE83571 (GSM2209767 - GSM2209776).

我们采用基因芯片（microarray）技术，对携带肿瘤的Sca1-TOMATO-Lmo2小鼠及该模型小鼠的白血病前期细胞的基因表达变化进行探究。整体实验设计：以11只Sca1-TOMATO-Lmo2小鼠的荷瘤胸腺为研究对象，分别与4只野生型（Wild Type, WT）小鼠的胸腺细胞、5只同模型小鼠的TOMATO阳性胸腺白血病前期T细胞，以及5只同模型小鼠的TOMATO阴性胸腺白血病前期T细胞进行比对分析。本研究中GSM2209749至GSM220975、GSM2209757至GSM2209759的样本数据，已通过数据集GSE83571（包含GSM2209767至GSM2209776）完成重新分析。