Metabolic dependencies of metastasis-initiating cells in breast cancer [RNA-seq]

We investigated gene expression changes in response to acetate treatment, which results in increased MIC-frequency, H3K27ac, and metastatic potential. Comparative gene expression analysis between cells that have been treated for 48 hours with vehicle or acetate treatment

本研究探究了乙酸盐处理诱导的基因表达变化，该处理可提升最低抑菌浓度频率（MIC-frequency）、组蛋白H3赖氨酸27乙酰化（H3K27ac）水平以及转移潜能；并对经溶剂对照或乙酸盐处理48小时的细胞进行了比较基因表达分析。