Additional file 6 of Comprehensive analysis of alternative splicing across multiple transcriptomic cohorts reveals prognostic signatures in prostate cancer

Additional file 6: Table S6. Differentially expressed splicing factors and prognostic alternative splicing events. (a) Results of the differential gene expression analysis of the splicing factors in the TCCGA-PRAD dataset. TCGA: The Cancer Genome Atlas; PRAD: prostate adenocarcinoma; logFC: log2 transformed fold change; AveExpr: average expression (log2-transformed) for the gene over all samples; t: moderated t-statistic; P.Value: raw p-value; adj.P.Val:adjusted p-value using Benjamini-Hochberg (BH) approach; B: log-odds. (b) Results of the univariate Cox regression analysis of the biochemical recurrence-free survival (BCRFS)-associated events in the TCGA-PRAD datasets. TCGA: The Cancer Genome Atlas; PRAD: prostate adenocarcinoma; z: the values of the Wald statistic; HR: hazard ratio of the event; HR.95L: the lower limit of 95% confidence interval; HR.95H: the upper limit of the 95% confidence interval; p: p-values obtained from the likelihood ratio test.

补充文件6：表S6。差异表达剪接因子与预后可变剪接事件。(a) 剪接因子在TCGA-PRAD数据集中的差异基因表达分析结果。其中：癌症基因组图谱（The Cancer Genome Atlas, TCGA）为肿瘤基因图谱项目；PRAD：前列腺腺癌（prostate adenocarcinoma）；logFC：经log2转换的倍数变化；AveExpr：所有样本中基因的平均表达量（经log2转换）；t：调节t统计量；P.Value：原始p值；adj.P.Val：采用Benjamini-Hochberg（BH）法校正的p值；B：对数胜算比。(b) TCGA-PRAD数据集中与生化无复发生存期（BCRFS）相关事件的单变量Cox回归分析结果。其中：TCGA：癌症基因组图谱（The Cancer Genome Atlas）；PRAD：前列腺腺癌（prostate adenocarcinoma）；z：Wald统计量值；HR：事件的风险比；HR.95L：95%置信区间下限；HR.95H：95%置信区间上限；p：似然比检验得到的p值。