BindingDB Entry 50038855: Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells.

Small molecule binding data for protein AKT/p21CIP1, CAMK2B, Cyclin-dependent kinase 1, Cyclin-dependent kinase 2, Death-associated protein kinase 1, Ephrin type-A receptor 3 (EPHA3), Ephrin type-B receptor 4 (EphB4), Epidermal growth factor receptor, Fibroblast growth factor receptor 1, Fibroblast growth factor receptor 2, Fibroblast growth factor receptor 3, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Glycogen synthase kinase-3, Hepatocyte growth factor receptor, Homeodomain-interacting protein kinase 1, Insulin receptor, Interleukin-1 receptor-associated kinase 4, JAK3/JAK1, Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET, MAP kinase ERK2, Misshapen-like kinase 1, Mitogen-activated protein kinase 3, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 (TAB1), Neurotrophic tyrosine kinase receptor, Phosphorylase kinase, Platelet-derived growth factor receptor, Protein kinase C alpha type, Receptor tyrosine-protein kinase erbB-4 (HER4), Rho-associated protein kinase, Ribosomal protein S6 kinase alpha 1, SRC, Serine/threonine-protein kinase Aurora, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase Chk2, Serine/threonine-protein kinase MST2, Serine/threonine-protein kinase PIM, Serine/threonine-protein kinase PLK2, TAK1/TAB1, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase BTK, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase SYK, Tyrosine-protein kinase receptor FLT3, VEGF-receptor 2 and tyrosine-protein kinase SRC, Vascular endothelial growth factor receptor, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), and p21-Activated kinase 2 (PAK2), Uniprot L7RSL3, O14757, O14965, O43318, O60674, O96017, P00519, P00533, P04629, P06213, P06239, P06493, P07948, P07949, P08581, P11309, P11362, P12931, P15735, P16234, P17252, P17948, P21802, P22607, P24941, P27361, P28482, P29320, P31749, P35916, P35968, P36888, P43405, P49841, P52333, P53355, P54760, Q02763, Q06187, Q13177, Q13188, Q13464, Q13554, Q15303, Q15418, Q15750, Q541P7, Q86Z02, Q8N4C8, Q9NWZ3, and Q9NYY3

本数据集包含蛋白AKT/p21CIP1、CAMK2B、细胞周期蛋白依赖性激酶1、细胞周期蛋白依赖性激酶2、死亡相关蛋白激酶1、Ephrin A型受体3（EPHA3）、Ephrin B型受体4（EphB4）、表皮生长因子受体、成纤维细胞生长因子受体1、成纤维细胞生长因子受体2、成纤维细胞生长因子受体3、黏着斑激酶1/血管内皮生长因子受体3、糖原合成激酶-3、肝细胞生长因子受体、同源结构域相互作用蛋白激酶1、胰岛素受体、白细胞介素-1受体相关激酶4、JAK3/JAK1、驱动蛋白-1重链/酪氨酸蛋白激酶受体RET、丝裂原活化蛋白激酶ERK2、类Misshapen激酶1、丝裂原活化蛋白激酶3、丝裂原活化蛋白激酶激酶激酶7相互作用蛋白1（TAB1）、神经营养性酪氨酸蛋白激酶受体、磷酸化酶激酶、血小板衍生生长因子受体、蛋白激酶C α亚型、受体酪氨酸蛋白激酶erbB-4（HER4）、Rho相关蛋白激酶、核糖体蛋白S6激酶α1、SRC、丝氨酸/苏氨酸蛋白激酶Aurora、丝氨酸/苏氨酸蛋白激酶Chk1、丝氨酸/苏氨酸蛋白激酶Chk2、丝氨酸/苏氨酸蛋白激酶MST2、丝氨酸/苏氨酸蛋白激酶PIM、丝氨酸/苏氨酸蛋白激酶PLK2、TAK1/TAB1、酪氨酸蛋白激酶ABL1、酪氨酸蛋白激酶BTK、酪氨酸蛋白激酶JAK2、酪氨酸蛋白激酶SYK、酪氨酸蛋白激酶受体FLT3、VEGF受体2与酪氨酸蛋白激酶SRC、血管内皮生长因子受体、血管内皮生长因子受体2、血管内皮生长因子受体2与酪氨酸蛋白激酶TIE-2（KDR与TIE2）以及p21活化激酶2（PAK2）的小分子结合数据，同时附带以下通用蛋白知识库（Uniprot）登录编号：L7RSL3、O14757、O14965、O43318、O60674、O96017、P00519、P00533、P04629、P06213、P06239、P06493、P07948、P07949、P08581、P11309、P11362、P12931、P15735、P16234、P17252、P17948、P21802、P22607、P24941、P27361、P28482、P29320、P31749、P35916、P35968、P36888、P43405、P49841、P52333、P53355、P54760、Q02763、Q06187、Q13177、Q13188、Q13464、Q13554、Q15303、Q15418、Q15750、Q541P7、Q86Z02、Q8N4C8、Q9NWZ3、Q9NYY3