Crystal Structure of the MerTK Kinase Domain in Complex with Inhibitor MIPS15692
收藏Protein Data Bank Japan2023-10-18 更新2026-03-21 收录
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Crystal Structure of the MerTK Kinase Domain in Complex with Inhibitor MIPS15692 Descriptor: 2-(butylamino)-N-[1-(3-fluoropropyl)piperidin-4-yl]-4-{[(1r,4r)-4-hydroxycyclohexyl]amino}pyrimidine-5-carboxamide, Tyrosine-protein kinase Mer Authors: Hermans, S.J, Hancock, N.C, Baell, J.B, Parker, M.W. Deposit date: 2021-03-25 Release date: 2021-10-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.06 Å) Cite: Development of [ 18 F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease. Eur.J.Med.Chem., 226, 2021
与抑制剂MIPS15692结合的MerTK激酶结构域晶体结构
配体描述符：2-(丁基氨基)-N-[1-(3-氟丙基)哌啶-4-基]-4-{[(1r,4r)-4-羟基环己基]氨基}嘧啶-5-甲酰胺
靶蛋白：酪氨酸蛋白激酶Mer
作者：Hermans, S.J.、Hancock, N.C.、Baell, J.B.、Parker, M.W.
提交日期：2021-03-25
发布日期：2021-10-06
最后修改日期：2023-10-18
实验方法：X射线衍射（3.06埃）
引用文献：《[¹⁸F]MIPS15692的开发：一种用于神经炎性疾病中MER酪氨酸激酶（MERTK）成像的体外概念验证放射性示踪剂》，Eur.J.Med.Chem., 226, 2021
创建时间：
2021-03-25
