IDENTIFICATION AND FUNCTIONAL DEMONSTRATION OF A FETAL-SPECIFIC AXIS THAT POTENTLY SUPPRESSES MLL-FUSION DRIVEN MURINE AML miRNA-seq [WT vs ME]

LIN28B suppresses MLL-ENL driven AML. The tumor suppressor effects of LIN28B are largely driven by positive regulation of MYBBP1A. miRNA-seq was performed on GMLPs from WT or iME mice (4 replicates per group).

LIN28B可抑制由MLL-ENL驱动的急性髓系白血病（AML）。LIN28B的肿瘤抑制效应主要通过正向调控MYBBP1A实现。本研究对野生型（WT）与iME小鼠的GMLPs开展了微小RNA测序（miRNA-seq），每组设置4个生物学重复。