Visium spatial transcriptomics of CCF1 MC38 tumors

In this study we investigated variation in responsiveness to anti-PD-1 using a model where we implanted the MC38 colorectal cancer cell line in genetically diverse host mice. This dataset consists of Visium spatial transcriptomics run on two isotype control-treated tumors from a responder Collaborative Cross F1 line and two from a non-responder Collaborative Cross F1 line.<br><br>

本研究采用将MC38结直肠癌细胞系（MC38 colorectal cancer cell line）接种至遗传多样性宿主小鼠体内的模型，探究了小鼠对抗PD-1（anti-PD-1）免疫治疗的应答差异。

本数据集包含对来自应答型协作杂交F1品系（Collaborative Cross F1 line）的2例经同型对照处理的肿瘤组织，以及来自非应答型协作杂交F1品系的2例经同型对照处理的肿瘤组织开展的Visium空间转录组（Visium spatial transcriptomics）测序数据。