Additional file 2 of Derivation and validation of urinary TIMP-1 for the prediction of acute kidney injury and mortality in critically ill children

Additional file 2: Fig. S1. Comparison of the initial (a) and peak (b) urinary biomarkers among patients with AKI status and/or death in the discovery cohort. Each dot represents an individual patient; the horizontal lines indicate medium with interquartile range. *P<0.05 vs. survivors with non-AKI, #P<0.05 vs. survivors with AKI stage 1 or 2. AKI acute kidney injury, FABP-1 fatty acid binding protein 1, IGFBP7 insulin-like growth factor-binding protein 7, IP-10 interferon inducible protein-10, KIM-1 kidney injury molecule-1, NGAL neutrophil gelatinase-associated lipocalin, TFF-3 trefoil factor-3, TIMP-1 tissue inhibitor of metalloproteinases-1, TIMP-2 tissue inhibitor of metalloproteinases-2. Each dot represents an individual patient; the horizontal lines indicate the median with interquartile range. *P<0.05 vs. survivors with non-AKI, #P<0.05 vs. survivors with AKI Stage ½.

附加文件2：图S1。发现队列中伴急性肾损伤（AKI，acute kidney injury）状态及/或死亡患者的初始（a）与峰值（b）尿液生物标志物对比。
每个圆点代表1名个体患者；横线表示中位数与四分位距。*P<0.05 与非AKI存活患者相比，#P<0.05 与AKI 1或2期存活患者相比。
AKI（acute kidney injury，急性肾损伤）；FABP-1（fatty acid binding protein 1，脂肪酸结合蛋白1）；IGFBP7（insulin-like growth factor-binding protein 7，胰岛素样生长因子结合蛋白7）；IP-10（interferon inducible protein-10，干扰素诱导蛋白10）；KIM-1（kidney injury molecule-1，肾损伤分子1）；NGAL（neutrophil gelatinase-associated lipocalin，中性粒细胞明胶酶相关脂质运载蛋白）；TFF-3（trefoil factor 3，三叶因子3）；TIMP-1（tissue inhibitor of metalloproteinases-1，金属蛋白酶组织抑制剂1）；TIMP-2（tissue inhibitor of metalloproteinases-2，金属蛋白酶组织抑制剂2）。
每个圆点代表1名个体患者；横线表示中位数与四分位距。*P<0.05 与非AKI存活患者相比，#P<0.05 与AKI ½期存活患者相比。