Johno_fig1.zip

./Fig1_S1:Mass spectra of plasma from 10 WHHL rabbits and 10 JW rabbits before (JW_HC0) and after (JW_HC16) 16-week exposure to a high-cholesterol diet were obtained by PESI-MS.These data are contained in the three files: "JW_HC0.tsv", "JW_HC16", and "WHHL.tsv". In each file, absolute intensities at m/z 10.0-1999.9 are represented for each rabbit. Sample IDs are listed in the header row.<br>./Fig2_S2-4:Six JW rabbits were given free access to a diet with (NC1-3) or without (HC1-3) supplemental cholesterol for 26 weeks. Plasma samples were collected every week and subjected to mass spectrometry by PESI-MS and biochemical analysis of TC, HDL-C, and TG. Mass spectral data of the six rabbits are contained in the folder "Spectra". The biochemical data are contained in the folder "Other_data". Data on body weights (BW) of the rabbits are also contained in this folder.<br>./Fig5:<br>The aortic wall of each rabbit at the sites of interest were collected by a biopsy punch, and inner layers of the aortic wall were homogenized with ethanol. After centrifugation of the solution, the supernatant was diluted with ethanol and subjected to analysis by PESI-MS. The representative two normalized mass spectra of each of the NC and HC aortae are contained in the two files: "NC.tsv" and "NC.tsv".

./图1_S1：采用探针电喷雾电离质谱（PESI-MS）获取了10只WHHL家兔与10只JW家兔在暴露于高胆固醇饮食16周前（JW_HC0）及暴露16周后（JW_HC16）的血浆质谱数据。该数据集包含三个文件："JW_HC0.tsv"、"JW_HC16"与"WHHL.tsv"。每个文件中均记录了每只家兔在质荷比（m/z）10.0~1999.9区间内的绝对强度值，样本ID列于表头行中。<br>./图2_S2~S4：将6只JW家兔分为两组，分别饲喂添加胆固醇（NC1-3）与不添加胆固醇（HC1-3）的饲料，自由进食26周。每周采集血浆样本，分别采用PESI-MS进行质谱检测，以及对总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）开展生化分析。6只家兔的质谱数据存储于"Spectra"文件夹中；生化数据与家兔体重（BW）数据均存储于"Other_data"文件夹内。<br>./图5：使用活检打孔器采集每只家兔目标部位的主动脉壁，将主动脉壁内层用乙醇进行匀浆处理。对匀浆液离心后，取上清液用乙醇稀释，随后采用PESI-MS进行分析。NC组与HC组主动脉各两份代表性归一化质谱数据分别存储于"NC.tsv"与"NC.tsv"文件中。