The Role of Neuro-Immune Interactions in the Pathology and Pathogenesis of Allergic Rhinitis

Allergic rhinitis (AR) is a non-infectious inflammatory disease of the nasal mucosa mediated by IgE and involving a variety of immune cells such as mast cells. In previous studies, AR was considered as an isolated disease of the immune system. However, recent studies have found that the nervous system is closely related to the development of AR. Bidirectional communication between the nervous and immune systems plays an important role in AR. The nervous system and immune system depend on the anatomical relationship between nerve fibers and immune cells, as well as various neurotransmitters, cytokines, inflammatory mediators, etc. to produce bidirectional connections, which affect the development of AR. This article reviews the impact of neuro-immune interactions in AR on the development of AR, including neuro-immune cell units.

过敏性鼻炎（Allergic rhinitis, AR）是一种由IgE介导、累及肥大细胞等多种免疫细胞的鼻黏膜非感染性炎性疾病。既往研究将过敏性鼻炎视为孤立的免疫系统疾病。然而近期研究发现，神经系统与过敏性鼻炎的发生发展密切相关。神经与免疫系统之间的双向通讯在过敏性鼻炎病程中发挥重要作用：二者依赖神经纤维与免疫细胞的解剖学关联，以及各类神经递质、细胞因子、炎性介质等建立双向连接，进而影响疾病的发生发展。本文综述了过敏性鼻炎中神经免疫交互作用对疾病发生发展的影响，包括神经免疫细胞单元。