Alberto Orta etal 2021: coverage data for 60 rat genomes

Coverage data from 60 re-sequenced rat genomes from the following work: Rats exhibit age-related mosaic loss of chromosome Y. Work by Alberto Orta, Diego Cortez and colleagues. The dataset contains two types of data for each of the 60 genomes: one with the normalized coverage (median values of 10,000 nucleotides long; normalized by sequencing depth) and a file containing the log2 ratios of old/young coverage data (median values of 10,000 nucleotides long). To avoid an error that comes from calculating log2 ratios of negative values, we recommend to add the value of 4 (minimum value in the dataset) to the normalized coverage data before performing the log2 ratios of old versus young normalized coverage values.

本数据集包含60头经重测序（re-sequenced）大鼠基因组的覆盖度（coverage）数据，源自研究论文《大鼠表现出与年龄相关的Y染色体嵌合缺失》，作者为Alberto Orta、Diego Cortez及其合作者。该数据集为60个基因组各提供两类数据：一类为标准化覆盖度（normalized coverage）数据（以10000核苷酸长度为窗口计算中位数，且已通过测序深度（sequencing depth）进行归一化处理）；另一类为包含老年/年轻组覆盖度数据log₂比值（log2 ratios）的文件，该比值同样以10000核苷酸长度为窗口计算中位数。为避免因对负值计算log₂比值时产生错误，建议在计算老年与年轻组标准化覆盖度的log₂比值前，向原始标准化覆盖度数据添加数值4（即该数据集的最小取值）。