Beneficial effects of ultrafine bubble shower on a mouse model of atopic dermatitis

Atopic dermatitis (AD) is a common chronic inflammatory disease. Recent studies have established genetic factors, deranged skin microbiome, skin barrier dysfunction, and immune dysregulation as critical etiologies of AD. Bathing and showering is the most important treatment to maintain physiological cutaneous barrier function and avoid an AD flare. Ultrafine bubbles (UFBs) are tiny bubbles in water with diameters of several tens to hundreds of nanometers. UFBs have also been used in showering or bathing. In a recent study comparing the UFB shower with a tap-water shower, the UFB shower resulted in a significantly higher stratum corneum water content 15 and 30 min after the shower (20). However, the effectiveness of UFB showers for skin diseases has not been studied. In the present study, we examined the effects of UFB shower on mouse models of AD. The effectiveness of UFB showers for skin diseases has not been studied. We examined the effects of UFB shower on mouse models of AD.

特应性皮炎（Atopic dermatitis, AD）是一种常见的慢性炎症性疾病。现有研究已明确，遗传因素、皮肤微生物群紊乱、皮肤屏障功能障碍及免疫失调为AD的关键致病因素。沐浴与淋浴是维持皮肤生理屏障功能、避免AD病情发作的最重要治疗手段。超细气泡（Ultrafine bubbles, UFBs）是指水中直径为数十至数百纳米的微小气泡。UFBs现已被应用于淋浴或泡澡场景。一项近期研究对比了超细气泡淋浴与自来水淋浴，结果显示，超细气泡淋浴后15分钟与30分钟时，皮肤角质层含水量显著更高（20）。然而目前尚无研究探讨超细气泡淋浴对皮肤疾病的疗效。本研究中，我们考察了超细气泡淋浴对AD小鼠模型的干预效果。