16S human for A Network of Bacterial Genera Associated with Therapeutic Response to Immune Checkpoint PD-1 Blockade in a United States Cohort

We used preserved fecal samples from a non-small cell lung cancer patients cohort, multi-omics analysis, and humanized gnotobiotic mouse models to decipher the link between microbiota and responsiveness to immune checkpoint inhibition treatment.

本研究采用非小细胞肺癌（non-small cell lung cancer）患者队列的留存粪便样本、多组学分析及人源化无菌小鼠模型，用以阐明菌群与免疫检查点抑制治疗响应之间的关联。