The effects of the global loss of DNA methylation on the functional cancer epigenome

We compare the global histone modification patterns of HCT116 colon cancer cells with its genetic derivatives DKO1 cells which lack DNMT3B and DNMT1 activity Overall design: Comparison of histone marks in two cell types

本研究比较了HCT116结肠癌细胞与其遗传衍生的DKO1细胞的全基因组组蛋白修饰模式，其中DKO1细胞缺失DNA甲基转移酶3B(DNMT3B)与DNA甲基转移酶1(DNMT1)的活性。实验设计概述：两种细胞类型的组蛋白标记物比较。