Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications

Abstract In this study, the preparation of a novel functional material for orthopedic implants using compression molding was investigated. The new functional material is envisioned to avoid inflammatory reactions in vivo after prosthesis implantation. Ibuprofen-loaded UHMWPE samples were prepared in two concentrations (3% and 5%) and samples were characterized in terms of physicochemical and mechanical properties. In addition, the drug-release profile was investigated. The manufacturing process resulted in a homogeneous polymer matrix with homogeneous drug dispersion. The addition of ibuprofen had a minor effect on physicochemical properties but a more significant influence on the mechanical behavior of the specimens was observed. Drug release was demonstrated and overall the results obtained showed a positive outcome with regard to the intended use. The properties analyzed remained within an acceptable range for medical application and the drug-release profile obtained for the material developed shows promise for its use as an anti-inflammatory system.

摘要 本研究探讨了采用模压成型工艺制备骨科植入物用新型功能材料的方法。该新型功能材料旨在避免假体植入后体内出现炎症反应。本研究制备了浓度分别为3%和5%的布洛芬负载超高分子量聚乙烯（Ultra High Molecular Weight Polyethylene, UHMWPE）样品，并对其理化性能与力学性能进行了表征；此外，还对该材料的药物释放曲线展开了研究。结果表明，该制备工艺可获得药物分散均匀的均质聚合物基体。布洛芬的添加对材料的理化性能影响较小，但对试样的力学性能具有更为显著的影响。实验证实了该材料的药物释放行为，整体而言，所得结果符合该材料的预期应用目标，呈现出积极效果。所分析的各项性能均处于医疗应用的可接受范围内，且所开发材料的药物释放曲线显示其作为抗炎体系具备良好的应用前景。