Dataset related to article "Psychological Characteristics of Inflammatory Bowel Disease Patients: A Comparison Between Active and Nonactive Patients."

BACKGROUND AND AIMS:

The role of new psychological factors such as psychopathological patterns and defense mechanisms in the care of inflammatory bowel disease (IBD) has been poorly investigated. We aimed to assess the psychological characteristics and defense mechanisms of IBD patients.

METHODS:

This was a single-center, observational, cross-sectional study. Consecutive adult IBD patients were enrolled and stratified according to disease activity. Sociodemographic and clinical data were collected, and validated questionnaires (Symptom Checklist-90-R [SCL-90-R]) for psychological distress, Defense Mechanism Inventory (DMI) for psychological defense mechanisms, and Inflammatory Bowel Disease Questionnaire (IBDQ) for quality of life (QoL) were administered.

RESULTS:

Two hundred one patients were enrolled: 101 in remission and 100 with active disease. The mean score for IBDQ was below the cutoff level (156.8 ± 37.8), with a significantly greater impairment of QoL in subjects with flares (136.5 vs 177.5, P < 0.001). Lower scores were associated with female gender. No patients had psychological scores above the cutoff for normality. Statistically higher SCL-90-R scores were found in active patients for obsessive-compulsive disorder (P = 0.026), depression (P = 0.013), anxiety (P = 0.013), phobic anxiety (P = 0.002), psychoticism (P = 0.007), global severity index (GSI) (P = 0.005) and positive symptom total (PST) (P = 0.001). A significantly increased probability of higher global indexes was associated with Crohn's disease and disease flares. None of the defensive Defense Mechanism Inventory (DMI) styles resulted above the cutoff in our cohort.

CONCLUSIONS:

Further data are needed to demonstrate the potential key role of psychological intervention in the therapeutic strategies utilized for IBD patients, and the identification of specific psychological patterns based on the patients profile is necessary to optimize psychological intervention.

背景与目的：目前针对精神病理模式、心理防御机制等新型心理因素在炎症性肠病（inflammatory bowel disease, IBD）诊疗中的作用研究尚少。本研究旨在评估炎症性肠病患者的心理特征与心理防御机制。

研究方法：本研究为单中心观察性横断面研究。纳入连续就诊的成年炎症性肠病患者，并根据疾病活动度进行分层。收集患者的社会人口学与临床资料，并采用经过验证的量表进行评估：用于评估心理痛苦的症状自评量表90-修订版（Symptom Checklist-90-R, SCL-90-R）、用于评估心理防御机制的防御方式问卷（Defense Mechanism Inventory, DMI），以及用于评估生活质量（quality of life, QoL）的炎症性肠病问卷（Inflammatory Bowel Disease Questionnaire, IBDQ）。

结果：本研究共纳入201例患者，其中101例处于疾病缓解期，100例为活动期。炎症性肠病问卷的平均得分低于临界值（156.8±37.8），疾病发作患者的生活质量受损程度显著更严重（136.5 vs 177.5，P<0.001）。得分较低与女性性别相关。所有患者的心理评分均未超出正常临界值。活动期患者在强迫症（P=0.026）、抑郁（P=0.013）、焦虑（P=0.013）、恐怖性焦虑（P=0.002）、精神病性（P=0.007）、总严重程度指数（global severity index, GSI）（P=0.005）及阳性症状总分（positive symptom total, PST）（P=0.001）方面的SCL-90-R得分显著更高。克罗恩病与疾病发作与更高的整体指数得分风险显著相关。本队列中无任何防御方式问卷的防御风格得分超出临界值。

结论：尚需更多研究数据以明确心理干预在炎症性肠病患者治疗策略中的潜在关键作用，同时需根据患者特征识别特定心理模式，以优化心理干预方案。