Intercepting Progression from Pre-Invasive to Invasive Lung Adenocarcinoma

An improved understanding of the biology of lung cancer is needed to intercept the disease at an early point in its progression. In this project we have used multidimensional methods to profile the tumor microenvironment (TME) and to determine the crosstalk between cancer cells and the TME in pre-invasive to invasive human lung non-solid adenocarcinomas. Comparative analysis of the cellular and molecular events associated with the distinct histological stages will lead to identification of the critical events triggering progression and thereby identify targets to intercept disease progression. The data being submitted represents the genomic profiles of patient samples with pre-invasive and invasive human lung adenocarcinomas.]]>
Inclusion Criteria:Any patient undergoing primary resection in the operating room for non small cell lung cancer.]]>

若要在肺癌进展早期阻断疾病进程，亟需深化对肺癌生物学特性的认知。本研究采用多维分析方法，对人类非实体型肺腺癌从浸润前到浸润性阶段的肿瘤微环境（Tumor Microenvironment）进行表征，并解析癌细胞与该微环境之间的交互串扰。针对不同组织学阶段相关的细胞与分子事件开展比较分析，将有助于明确驱动疾病进展的关键事件，进而确定可用于阻断疾病进展的干预靶点。本次提交的数据涵盖了浸润前及浸润性人类肺腺癌患者样本的基因组表征信息。
纳入标准：所有因非小细胞肺癌在手术室接受根治性切除术的患者。