Gene expression profiling of CD34+ subsets in Multiple Myeloma and healthy individuals

Multiple myeloma (MM) is a clonal plasma cell disorder frequently accompanied by hematopoietic impairment. Genomic profiling of distinct HSPC subsets revealed a consistent deregulation of signaling cascades, including TGF beta signaling, p38MAPK signaling and pathways involved in cytoskeletal organization, migration, adhesion and cell cycle regulation in MM patients. CD34+ subsets of 7 patients with Multiple Myeloma and 5 healthy volunteers were analysed by means of gene expression profiling with the Affymetrix HU-133A 2.0 array

多发性骨髓瘤（Multiple Myeloma, MM）是一类克隆性浆细胞疾病，常伴随造血功能受损。对不同造血干祖细胞（Hematopoietic Stem and Progenitor Cells, HSPC）亚群开展基因组谱分析后发现，多发性骨髓瘤患者体内存在多条信号通路的持续失调，包括转化生长因子β（TGF-β）信号通路、p38丝裂原活化蛋白激酶（p38MAPK）信号通路，以及参与细胞骨架组织、细胞迁移、细胞黏附与细胞周期调控的相关通路。本研究采用Affymetrix HU-133A 2.0 基因芯片，对7例多发性骨髓瘤患者与5名健康志愿者的CD34阳性（CD34+）造血干祖细胞亚群进行了基因表达谱分析。