gut microbiome of prebiotic-treated NFLD patients

A cohort of NAFLD patients was randomized for a prebiotic (Inulin) 12 weeks treatment (n=8) and a placebo treatment (n=11). Fecal microbiome and metabolic, inflammatory, and liver parameters were assessed at baseline and at end of treatment. Inulin signifcantly increased relative abundance of Bifidobacterium, but did not significantly alter liver-related clinical parameters.

本队列研究纳入一批非酒精性脂肪性肝病（Non-Alcoholic Fatty Liver Disease, NAFLD）患者，将其随机分为两组：益生元（Prebiotic）菊糖（Inulin）干预组（接受12周治疗，n=8）与安慰剂对照组（n=11）。研究人员在基线状态与治疗结束时，分别对受试者的粪便微生物组、代谢指标、炎症指标及肝脏相关参数进行检测与评估。结果显示，菊糖可显著提升双歧杆菌（Bifidobacterium）的相对丰度，但未对肝脏相关临床参数造成显著改变。