The curative effects of methylsulfonylmethane against glycerol-induced acute renal failure in rats

Abstract The present study was performed to explore the curative effect of Methylsulfonylmethane (MSM) in an experimental model of myoglobinuric acute renal failure (ARF). In this experimental model, Rats were injected with 50% glycerol (10 mL/kg, im) followed by an hour later and daily in the next six days by MSM (400 mg/kg) or saline. Kidney’s function (urea and creatinine), and reduced glutathione were analyzed. A renal failure produced by glycerol injection, with a significant increase of blood urea and serum creatinine was observed. Rats that received MSM in addition to glycerol had significantly lower blood urea and serum creatinine levels compared to those receiving glycerol alone. However, glutathione has markedly increased after MSM treatment. The effect is probably due to the antioxidant activity of MSM. This may provide therapeutic opportunities for treating humans, myoglobinuric ARF.

摘要 本研究旨在探究二甲基砜（Methylsulfonylmethane，MSM）在肌红蛋白性急性肾衰竭（myoglobinuric acute renal failure，ARF）实验模型中的治疗效果。该实验模型中，大鼠经50%甘油（10mL/kg，肌内注射）造模，造模1小时后及后续6天每日给予二甲基砜（400mg/kg）或生理盐水。随后对肾脏功能指标（血液尿素与血清肌酐）及还原型谷胱甘肽水平进行检测。结果显示，甘油注射造模可诱导急性肾衰竭，大鼠血液尿素与血清肌酐水平显著升高；相较于仅接受甘油造模的大鼠，联合给予二甲基砜的大鼠血液尿素与血清肌酐水平显著降低。此外，二甲基砜处理后大鼠体内还原型谷胱甘肽水平显著升高。该作用可能源于二甲基砜的抗氧化活性，或可为人类肌红蛋白性急性肾衰竭的治疗提供新的契机。