Resection Versus Microwave Ablation for Resectable Colorectal Cancer Liver Metastases

This single-center, prospective, randomized clinical trial is designed to compare the clinical characteristics and outcomes of hepatic resection and microwave ablation (MWA) to determine the optimal operative intervention for the local treatment of resectable colorectal cancer liver metastases. The primary aim of this study is to test the following hypothesis: 2-year local disease control is equivalent between patients receiving the experimental therapy (MWA) and patients receiving the standard therapy (hepatic resection) as treatment for colorectal cancer liver metastases determined to be resectable by radiographic imaging. Secondarily, the investigators expect that 2-year intrahepatic (regional) and metastatic disease recurrence rates are equivalent between the two treatment arms in this study.

本项单中心、前瞻性、随机对照临床试验旨在对比肝切除术与微波消融（MWA）的临床特征及治疗结局，以明确可切除结直肠癌肝转移局部治疗的最优手术干预方案。本研究的主要目的为验证如下假设：经影像学确认可切除的结直肠癌肝转移患者，接受试验性治疗（MWA）与标准治疗（肝切除术）后的2年局部疾病控制率相当。次要研究目的为，本研究中两组治疗人群的2年肝内（区域）转移性疾病复发率无显著差异。