Characteristic molecular signature of pericardial effusion identifies malignant cancer in pericardial disorder patients. Characteristic molecular signature of pericardial effusion identifies malignant cancer in pericardial disorder patients

we examined 24 pericardial effusion patients and obtained pericardial fluid. To identify novel biomarker for detection cancer, detected transcriptome-based molecualr signature of compare pathologic cancer patients and non-cancer patients. Overall design: 19 patients were dichotomized cancer group (Group 1) and non-cancer (Group 3) group. Group 1 (n=6) and Group 3 (n=5) were analyzed on whole genome expression microarray to profile pericardial fluid with cancer characteristic molecuar signature.

本研究纳入24例心包积液（pericardial effusion）患者并采集其心包液（pericardial fluid）样本。为筛选可用于癌症检测的新型生物标志物（biomarker），本研究通过对比病理确诊的癌症患者与非癌症患者，开展基于转录组（transcriptome）的分子特征分析。实验总体设计：将19例患者划分为癌症组（组1）与非癌症组（组3）；对组1（n=6）与组3（n=5）的样本开展全基因组表达微阵列（whole genome expression microarray）检测，以刻画具有癌症特征的心包液分子特征谱。