3D cyto- and receptor architectonic map of macaque orbitofrontal area 12o (v1.0)

A multimodal analysis of the macaque prefrontal cortex was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This project involved a quantitative and statistically testable approach to the analysis of cytoarchitecture in the macaque monkey frontal lobe, in combination with an in vitro quantitative receptor autoradiographic analysis of the regional and laminar distribution patterns of 14 different neurotransmitter receptors. The borders of the identified areas were traced onto a reference macaque monkey brain in stereotaxic space. We provide here for the first time a map of orbitofrontal area 12o of the macaque monkey brain integrating cyto- and receptor architectonic features in stereotaxic space. It constitutes a valuable resource for the analysis of functional experiments with non-human primates and provides crucial data for modeling approaches with realistic synaptic dynamics.

本研究通过多模态分析猕猴前额叶皮层，旨在构建一套三维图谱，以整合并协调既往已发表的图谱间存在的差异。本项目采用定量且可经统计学检验的分析方法，对猕猴额叶的细胞构筑（cytoarchitecture）展开研究，并结合体外定量受体放射自显影（receptor autoradiographic）分析技术，解析14种不同神经递质受体的区域与层状分布模式。将所识别脑区的边界描记至立体定向空间（stereotaxic space）中的标准猕猴脑模板上。本研究首次提供了猕猴脑眶额叶12o区的图谱，该图谱整合了立体定向空间下的细胞构筑与受体构筑特征。本资源可为非人灵长类（non-human primates）的功能实验分析提供宝贵参考，同时也为基于真实突触动力学（synaptic dynamics）的建模研究提供关键数据支撑。