<b>Obesity Indices, Inflammation, and Sex Steroid Hormones in Children and Adolescents: A Cross-Sectional Analysis of NHANES 2013-2016</b>

<b>背景</b>：与传统的体重指数 （BMI） 相比，较新的肥胖指数，如身体圆度指数 （BRI） 和 A 体型指数 （ABSI），在表征身体脂肪分布模式方面表现出卓越的能力。然而，BRI 和 ABSI 与儿童和青少年性类固醇激素的关联仍然很清楚。此外，虽然全身炎症被认为会破坏荷尔蒙调节，但肥胖指数和全身炎症总指数（AISI）对性类固醇激素的综合影响仍未完全研究。<b>方法</b>：<b> </b>这项横断面分析利用了全国健康与营养检查调查（NHANES，2013-2016）中 3,326 名 6-19 岁参与者的数据。采用加权线性回归模型评估肥胖指数和AISI对性类固醇激素的个体和综合影响，特别是雌二醇（E2）、总睾酮（TT）、性激素结合球蛋白（SHBG）和游离雄激素指数（FAI）。<b>回复</b><b>苏尔特</b>：<b> </b>在 3,326 名参与者中，平均年龄为 12.80 岁，其中男性 1,691 人。与低肥胖指数和低AISI的参考组相比，高BMI和高AISI组合与E2、SHBG和FAI的关联最强，而高ABSI和高AISI组合与TT的关联最强。<b>结论</b>：<b> </b>BMI、BRI、ABSI和AISI与儿童青少年性类固醇激素显著相关。至关重要的是，肥胖指数与炎症标志物的联合评估显着增强了预测性类固醇激素变异的能力。<b>Background</b>: Compared with the traditional body mass index (BMI), newer obesity indices such as the body roundness index (BRI) and abdominal body shape index (ABSI) have exhibited superior efficacy in characterizing body fat distribution patterns. However, the associations between BRI, ABSI and sex steroid hormones in children and adolescents remain clear. Furthermore, although systemic inflammation is recognized to disrupt hormonal regulation, the combined effects of obesity indices and the overall systemic inflammation index (AISI) on sex steroid hormones have not been fully investigated. <b>Methods</b>: This cross-sectional analysis utilized data from 3,326 participants aged 6 to 19 years enrolled in the National Health and Nutrition Examination Survey (NHANES, 2013–2016). Weighted linear regression models were employed to evaluate the individual and combined impacts of obesity indices and AISI on sex steroid hormones, specifically estradiol (E2), total testosterone (TT), sex hormone-binding globulin (SHBG) and free androgen index (FAI). <b>Results</b>: Among the 3,326 participants, the mean age was 12.80 years, with 1,691 males. Compared with the reference group with low obesity indices and low AISI, the combination of high BMI and high AISI demonstrated the strongest associations with E2, SHBG and FAI, while the combination of high ABSI and high AISI exhibited the strongest association with TT. <b>Conclusions</b>: BMI, BRI, ABSI and AISI are significantly associated with sex steroid hormones in children and adolescents. Importantly, the combined assessment of obesity indices and inflammatory markers significantly enhanced the capacity to predict variations in sex steroid hormones.