Expression profiling of murine DCIS and invasive ductal breast carcinoma

Murine healthy tissue samples, DCIS and invasive mammary tumors were analyzed in order to identify marker genes which show enhanced expresssion in DCIS and invasive ductal carcinomas. Using this approach, we were able to identify a set of genes which might allow a better detection of DCIS and invasive carcinomas in the future. Samples consists of: 5 wild type breast tissue samples 5 healthy breast tissue sapmles of WAP-TNP8 mice 5 samples of mice one month, 5 samples of mice two month, 5 samples of mice three month, 5 samples of mice four month, and 5 samples of mice five month after activation of the SV40 oncogene 5 invasive tumors

本研究对小鼠健康组织样本、导管原位癌（Ductal Carcinoma In Situ，DCIS）及侵袭性乳腺肿瘤开展分析，旨在筛选出在DCIS与侵袭性导管癌中表达上调的标记基因。通过该分析策略，本研究成功鉴定得到一组基因，有望在未来实现对DCIS及侵袭性癌的更精准检测。本次分析的样本包括：5份野生型乳腺组织样本、5份WAP-TNP8小鼠健康乳腺组织样本、SV40癌基因激活后1个月、2个月、3个月、4个月及5个月的小鼠组织样本各5份，以及5份侵袭性肿瘤样本。