Adverse Outcome Pathway on Binding to voltage gate sodium channels during development leading to cognitive impairment

Organisation for Economic Co-operation and Development2026-04-11 收录

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This adverse outcome pathway links the binding of xenobiotics to voltage gate sodium channels (VGSCs) during development, to cognitive impairment. The binding of xenobiotics to VGSCs may lead to disruption of action potential generation and consequently to an alteration in neurotransmission. Neurotransmitter release is essential for neural...

本不良结局途径（Adverse Outcome Pathway）将发育过程中外源性化学物（xenobiotics）与电压门控钠通道（voltage-gated sodium channels, VGSCs）的结合，与认知障碍建立了关联。外源性化学物与VGSCs的结合可干扰动作电位的产生，进而造成神经传递过程的改变。神经递质释放对于神经……