Pharmacokinetic parameters of paclitaxel/17-AAG-loaded micelles in comparison with those of the free drugs in tumor-bearing mice (mean ± SD, n = 4).

Abbreviations:t1/2: elimination half-life; AUC: area under the plasma drug concentration versus time curve; CLT: total clearance; VD,SS: apparent volume of distribution at the steady-state.

缩写说明：t1/2：消除半衰期（elimination half-life）；AUC：血浆药物浓度-时间曲线下面积（area under the plasma drug concentration versus time curve）；CLT：总清除率（total clearance）；VD,SS：稳态表观分布容积（apparent volume of distribution at the steady-state）。