Supplementary Material for: Liver Abscess due to <b><i>Streptococcus intermedius</i></b> Bacteremia and Its Association with Colonic Carcinoma: Is Bacteremia with <b><i>Streptococcus intermedius</i></b> an Alert for Colonic Carcinoma?
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Liver abscess caused by some kinds of <i>Streptococcus</i> group such as <i>Streptococcus bovis</i> group has been recognized to associate with colorectal cancer. <i>Streptococcus milleri</i> group with liver abscess has not been received much attention in this point of view. Here, we report the case of a 63-year-old man who developed liver abscess with <i>S. intermedius</i>, which belongs to the <i>S. milleri</i> group. We confirmed that this case was accompanied by cecal carcinoma by colonoscopy. The tumor was a pathological lead point of intussusception of cecum. On the 26th day, open right hemicolectomy was performed. In this case, bacterial endophthalmitis was a complication due to bacteremia. The patient underwent ophthalmic surgery on the 98th day. Research investigating 16S rRNA of the mucosal colon microbiome reported that the <i>S. intermedius</i> gene was upregulated in patients with colorectal carcinoma. It is recommended that liver abscess with <i>S. intermedius</i> bacteremia should alert the clinician about the risks of carcinoma of the colon and abscess formation in distant organs. We here list the case reports of liver abscess caused by <i>Streptococcus</i> other than <i>S. bovis</i> group, which was associated with colonic carcinoma, and suggest the need for further research about <i>S. milleri</i> group.
由某些链球菌（Streptococcus）群（如牛链球菌群（Streptococcus bovis））引发的肝脓肿，已被证实与结直肠癌存在关联。而米勒链球菌群（Streptococcus milleri）合并肝脓肿的相关研究，在这一关联视角下尚未受到足够重视。本文报告1例63岁男性患者，其罹患了由中间链球菌（S. intermedius）引发的肝脓肿，该菌隶属于米勒链球菌群。经结肠镜检查（colonoscopy）确认，该患者同时患有盲肠癌（cecal carcinoma），该肿瘤为盲肠肠套叠（intussusception）的病理性起始点。患者于发病后第26日行开腹右半结肠切除术（open right hemicolectomy）。本病例并发了菌血症（bacteremia）所致的细菌性眼内炎（bacterial endophthalmitis），患者于发病后第98日行眼科手术。有针对结肠黏膜微生物组（mucosal colon microbiome）16S rRNA的研究显示，结直肠癌患者体内的中间链球菌基因表达上调。因此，当临床遇到合并中间链球菌菌血症的肝脓肿病例时，应警惕结直肠癌及远处器官脓肿形成的风险。本文汇总了除牛链球菌群外、与结肠癌相关的链球菌性肝脓肿病例报告，并提出需针对米勒链球菌群开展进一步研究。
