Determinants of generic and specific health-related quality of life in patients with Parkinson’s disease

Objectives
Generic and disease-specific health-related quality of life (HRQoL) instruments may reflect different aspects of lives in patients with Parkinson’s disease (PD) and thus be associated with different determinants. We used the same cluster of predictors for the generic and disease-specific HRQoL instruments to examine and compare the determinants of HRQoL.
Method
HRQoL was measured in 92 patients with PD by the 36-item Short-Form Health Survey (SF-36) and the 39-item Parkinson’s Disease Questionnaire (PDQ-39). The predictors included demographic and disease characteristics, and motor and non-motor symptoms. Multiple regression analyses were used to identify HRQoL determinants.
Results
Depressive symptoms and motor difficulties of daily living were the first two significant determinants for both instruments. The other significant determinant for the SF-36 was fatigue and non-motor difficulties of daily living, and for the PDQ-39 was motor signs of PD.
Conclusions
The results suggest the importance of the evaluation and intervention focused on depressive symptoms and motor difficulties of daily living in patients with PD. In addition, the SF-36 seems more related to non-motor symptoms, while the PDQ-39 appears more associated with motor symptoms. This information is important for understanding results from these two instruments and for choosing which to use.

研究目的
普适性与疾病特异性健康相关生存质量（Health-Related Quality of Life, HRQoL）评估工具可反映帕金森病（Parkinson’s Disease, PD）患者生活的不同维度，因此与不同的影响因素相关联。本研究采用同一组预测变量，分别针对普适性与疾病特异性健康相关生存质量评估工具，对健康相关生存质量的影响因素进行探究与对比分析。

研究方法
本研究采用36条目简明健康调查量表（36-item Short-Form Health Survey, SF-36）与39条目帕金森病问卷（39-item Parkinson’s Disease Questionnaire, PDQ-39），对92例帕金森病患者的健康相关生存质量进行评估。预测变量涵盖人口学特征、疾病相关特征以及运动与非运动症状。本研究采用多元回归分析方法，明确健康相关生存质量的影响因素。

研究结果
对于两类评估工具而言，抑郁症状与日常生活运动障碍均为排名前两位的显著影响因素。针对36条目简明健康调查量表（SF-36），其余显著影响因素为疲劳与日常生活非运动障碍；而针对39条目帕金森病问卷（PDQ-39），其余显著影响因素则为帕金森病运动体征。

研究结论
本研究结果提示，针对帕金森病患者的抑郁症状与日常生活运动障碍开展评估与干预具有重要意义。此外，36条目简明健康调查量表（SF-36）与非运动症状的关联性更强，而39条目帕金森病问卷（PDQ-39）则更侧重于反映运动症状。该研究结果有助于理解两类评估工具的测评结果，并为工具的选择提供参考依据。