CuSO4‑Mediated Decarboxylative Difluoroacetamidation of α,β-Unsaturated Carboxylic Acids

The first example of decarboxylative difluoroacetamidation of α,β-unsaturated carboxylic acids by using difluoromethyl-substituted carbonyl compounds was disclosed. The procedure, which was mediated by low-cost and benign CuSO4, furnished a broad range of difluorinated alkenes in remarkable yields with only the E configuration in most of the cases. Moreover, the product could be smoothly transformed to the corresponding difluorofunctionalized ester and alcohol in high yields.

本研究首次报道了以二氟甲基取代羰基化合物为底物，实现α,β-不饱和羧酸的脱羧二氟乙酰氨基化反应。该反应以低成本且环境友好的硫酸铜（CuSO4）作为介导试剂，可得到一系列二氟代烯烃类产物，多数情况下仅生成E型构型产物且收率优异。此外，所得产物可经温和转化，以高收率得到对应的二氟官能化酯与醇类化合物。