Human Immunology Project Consortium Database

The Human Immunology Project Consortium (HIPC) program, an organization founded by the NIAID-DAIT, released ImmuneSpace in January 15, 2016. ImmuneSpace blossomed from a shared idea that generating large amounts collaborative data, cross-center and cross-assay, to characterize the status of the immune system in diverse populations under normal conditions and in response to various stimuli would be a beneficial platform. Since its release, ImmuneSpace has developed into powerful data management and analysis engine, where datasets can be easily explored and analyzed using state-of-the-art computational tools. ImmuneSpace takes advantage of the considerable infrastructure already developed through another HIPC platform, ImmPort, which serves as a repository of data generated by investigators funded by DAIT. Data are submitted by each HIPC center to ImmPort using a set of standardized data templates. Once ImmPort has made these data public through routine data releases, the data are transferred to ImmuneSpace where integrative modeling across various data types and HIPC centers are enabled. ImmuneSpace provides multiple ways to interact with, visualize, and analyze data. Each study contains tabs to view raw data, run common analyses, and look at custom reports. All the analyses make use of the R statistical language, leveraging Rserve to improve performance and knitr to enable full reproducibility.

由美国国家过敏与传染病研究所-艾滋病与免疫治疗分部（NIAID-DAIT）发起成立的人类免疫学项目联盟（Human Immunology Project Consortium, HIPC），于2016年1月15日正式发布免疫空间（ImmuneSpace）。免疫空间的构想源于一项共识：通过跨中心、跨检测实验生成大规模协作数据，以刻画正常生理状态下及受各类刺激后不同人群的免疫系统状态，该平台将具备极高应用价值。自发布以来，免疫空间已发展为功能强大的数据管理与分析引擎，用户可借助前沿计算工具便捷探索并分析数据集。免疫空间依托HIPC旗下另一平台免疫端口（ImmPort）已建成的成熟基础设施——该平台作为由DAIT资助的研究者所产出数据的存储库。各HIPC中心通过一套标准化数据模板将数据提交至ImmPort。当ImmPort通过常规数据发布将上述数据公开后，数据会被迁移至免疫空间，在此可实现跨多种数据类型及HIPC中心的整合建模。免疫空间提供多种数据交互、可视化与分析途径，每项研究均设有专属标签页，用于查看原始数据、执行常规分析及查阅自定义报告。所有分析均采用R统计语言（R），通过调用Rserve（Rserve）提升运行性能，并借助knitr（knitr）实现完整的可复现性。

搜集汇总

背景与挑战

背景概述

该数据集是人类免疫学项目联盟（HIPC）的数据库平台ImmuneSpace，由NIAID过敏、免疫和移植部门建立。它整合了来自多中心的人类免疫反应数据，涵盖疫苗接种、感染和疾病等扰动，并提供数据查询、分析和可视化工具，以支持免疫系统的研究。